DNA Alterations in Lynch Syndrome: Advances in molecular diagnosis and genetic counsellingFrom Springer
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DNA Alterations in Lynch Syndrome: Advances in molecular diagnosis and genetic counsellingFrom Springer
Read Online and Download Ebook DNA Alterations in Lynch Syndrome: Advances in molecular diagnosis and genetic counsellingFrom Springer
Lynch syndrome (LS) is the most common cause of inherited colorectal cancer, a disease with a high mortality rate. An estimated 37,000 of diagnosed colorectal cancer cases worldwide are attributed to Lynch syndrome each year. Intensive cancer screening, with early initiation and frequent follow-up, can reduce colorectal cancer incidence and mortality in LS patients. This book provides an up-to-date overview on the genetic and epigenetic basis of Lynch syndrome. It evaluates clinical features of the disease and critically comments on molecular tools available for identifying mutations responsible for Lynch syndrome; in addition the importance of functional assays that can help clarify the clinical nature of identified mutations is also discussed. The book also focuses on challenges in genetic counselling of at-risk individuals and discusses related ethical issues. The purpose of the book is to give a concise knowledge base for the broader scientific and medical community, including genetic counselors, in order to improve awareness on the potential impact that the diagnosis of LS has on treatment, management and surveillance of LS patients.
DNA Alterations in Lynch Syndrome: Advances in molecular diagnosis and genetic counsellingFrom Springer- Published on: 2015-06-24
- Released on: 2015-06-24
- Original language: English
- Number of items: 1
- Dimensions: 9.25" h x .49" w x 6.10" l, .66 pounds
- Binding: Paperback
- 195 pages
Review
From the reviews:
“This highly specialized book is an extensive, multiauthored discussion of Lynch syndrome. … From health professionals implementing general health surveillance to oncologists and geneticists dealing with populations at risk of Lynch syndrome, this is a must-have book. Cancer genetics clinics should count this as part of their resources to provide accurate information to their patients. … There are no comparable publications. This book is unique in its concentration on a single disorder, and it achieves its goals with outstanding writing and planning.” (Luis F. Escobar, Doody’s Book Reviews, October, 2013)From the Back Cover
Lynch syndrome (LS) is the most common cause of inherited colorectal cancer, a disease with a high mortality rate. An estimated 37,000 of diagnosed colorectal cancer cases worldwide are attributed to Lynch syndrome each year. Intensive cancer screening, with early initiation and frequent follow-up, can reduce colorectal cancer incidence and mortality in LS patients. This book provides an up-to-date overview on the genetic and epigenetic basis of Lynch syndrome. It evaluates clinical features of the disease and critically comments on molecular tools available for identifying mutations responsible for Lynch syndrome; in addition the importance of functional assays that can help clarify the clinical nature of identified mutations is also discussed. The book also focuses on challenges in genetic counselling of at-risk individuals and discusses related ethical issues. The purpose of the book is to give a concise knowledge base for the broader scientific and medical community, including genetic counselors, in order to improve awareness on the potential impact that the diagnosis of LS has on treatment, management and surveillance of LS patients.
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Most helpful customer reviews
1 of 1 people found the following review helpful. Nice work, very complete. Quite some overlap between chapters, though. By Mark For people working/interested in this field this is a very nice book. It covers pretty much all relevant aspects of this field. I do think that there is significant overlap between chapters, especially between chapters 3 and 4.
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